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When to increase dose Consider increasing if: Minimal response after 4-6 weeks at current dose No side effects at current dose Current dose below the higher end of recommended range Goals not being met with conservative approach Increase gradually, typically by 25-50% at a time

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The combination is safe and effective for Fitzpatrick III to V skin when the needle depth and session frequency are calibrated conservatively, and when the patient follows consistent sun protection

Pregnant and breastfeeding women have no safety data for the injectable form and should be cautious with topical use

Glide across areas of thinning