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10.3 Perspectives: from a single drug to an adaptive precision-care paradigm Future progress in this field will depend not only on more effective agents, but also on higher-quality reproductive evidence and better integration of metabolic, reproductive, and safety endpoints into clinical pathway design

By inhibiting NNMT, the compound prevents the depletion of both NAD+ and SAM in adipocytes, two factors that are critical for maintaining metabolic flexibility

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Clinical trials used the same dosing for both men and women

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