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These include: Nausea (very common, affecting more than 1 in 10 people) Diarrhoea (very common) Vomiting (common, affecting up to 1 in 10 people) Constipation (common) Abdominal pain (common) Reduced appetite (very common) These gastrointestinal effects typically occur during dose escalation and often diminish over time as the body adjusts to the medication

Anti-PD-1 therapy reduced tumors by ~5-fold

Topical application targets localized skin concerns

Randomized, placebo controlled, double-blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin

Vallon, V., Blantz, R

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