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The American Society of Anesthesiologists (ASA) recommends the following for patients on weekly GLP-1 agonists: Stop taking the medication for one week prior to elective procedures If you have severe nausea, vomiting, or abdominal pain on the day of surgery, the procedure may need to be delayed Of course, you should consult both your prescribing provider and your surgeon for guidance specific to your particular situation

Recent data have indicated that such an effect may depend on the influence on metabolic processes because in chronic unpredictable mild stress (CUMS) in mice, the decreased GLP-1 level in the hippocampus was increased with metformin treatment [46]

Similar to primary analysis findings, active use of NSAIDs and steroids increased the risk for peptic ulcer disease

Research dosages range from 900 to 2000 mg per day

doi: 10.1111/dom.12932 63 SevignyJChiaoPBussireTWeinrebPHWilliamsLMaierMet al