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Because safety data remains limited, patients should avoid extended cycles unless a qualified provider determines that continued use is appropriate.

In parallel, in-depth mechanistic studies could identify the precise biological mechanisms underlying the association between ACs and depression

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Ibutamoren (MK-677): Safety Safety considerations for ibutamoren (MK-677) may include the following: Increased fasting blood glucose levels Potential impact on insulin sensitivity Risk of fluid retention Clinical trials were discontinued early due to concerns about potential cardiovascular effects