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Also, anxiety-like behavior was measured in the EPM [37, 40], DLB [34, 42], OFT [34], and hole board test (HBT) [37], and memory in the object recognition test (ORT) [42]

10.1016/j.bcp.2021.114584 134 YanH

One open-label pilot study (Honda et al., PMC5548760, n=29 NAFLD patients) found that 300 mg/day reduced ALT and liver fat markers, but this was a clinical population without a control group

Benefits of metformin in attenuating the hallmarks of aging

It also plays crucial roles in the immune response, DNA repair, mitochondrial function and the detoxification of drugs, chemicals, heavy metals, radiation, metabolic wastes, and other toxins and carcinogens