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As a central transcription factor, NRF2 influences this cell death mode by inducing a variety of genes including SLC7A11, GPX4, FSP1, NQO1, HMOX1, ferritin heavy chain 1 (FTH1), HECT and RLD domain-containing E3 ubiquitin protein ligase 2, and vesicle-associated membrane protein 8 in hepatocellular carcinoma and ovarian cancer cells [85, 86]

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Its ability to reduce pro-inflammatory cytokines and improve microcirculation suggests a powerful role in easing joint pain, muscle fatigue, and connective tissue strain

Loss of myeloid related protein-8/14 exacerbates cardiac allograft rejection

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