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Selectively targeting glutamine uptake by L--Glutamyl-p-nitroanilide (GPNA), an inhibitor of glutamine transporter SLC1A5, showed a reduction of tumor proliferation in a preclinical 3D model and tumor growth suppression in a xenograft when combined with castration of mice [152]

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Schfer is also looking ahead: "We hope that our results will contribute to the future production of psilocybin for pharmaceuticals in bioreactors without the need for complex chemical syntheses." At the Leibniz-HKI in Jena, Hoffmeister's team is working closely with the Bio Pilot Plant, which is developing processes for producing natural products such as psilocybin on an industry-like scale

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A map generated by 3D refinement was subsequently post-processed in DeepEMhancer 35