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doi:10.5301/ijao.5000024

Houten SM, Wanders RJA, Ranea-Robles P

Erythropoietic protoporphyria , caused by ferrochelatase deficiency producing phototoxic protoporphyrin IX accumulation in erythrocytes, plasma, and skin , provides a research model for studying MC1R-mediated photoprotection in a disease context where protection from visible light-induced phototoxicity is the primary biological endpoint

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The study also highlighted that the efficacy of probiotics is highly individualized (123)

(2020) specifically addressed NSAID-induced gut damage a clinically relevant injury model and documented that BPC-157 administration stabilized the claudin-4 and occludin tight junction proteins that are degraded by NSAID exposure, providing a mechanistic explanation for the peptides permeability-protective effects