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Sandra Handgraaf, Rodolphe Dusaulcy, Florian Visentin, Jacques Philippe, Yvan Gosmain Estradiol increases GLP-1 release from human - and L cells in vitro.
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While the trial was not designed to formally disentangle weight lossmediated vs weightindependent mechanisms, the magnitude and durability of weight loss likely play a substantial role in risk modification. Clinicians should note that in SELECT, treatment discontinuation due to adverse events was 16% on semaglutide vs 8% on placebo, largely driven by GI events
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This dual targeting is designed to help patients manage their glucose levels more effectively and support weight loss
