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Similarly, in chronic myeloid leukaemia (CML), co-inhibition of Trx1 and glutamate-cysteine ligase may serve as a therapeutic strategy for both imatinib-sensitive and drug-resistant patients by triggering ferroptosis (75)

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The bound peptides (GLP-1, tirzepatide and peptide 20) overlapped well and penetrated into the receptor TMD core by an identical angle and orientation, thereby exploiting a similar ligand recognition pattern for most residues except for a few positions that have distinct amino acids (Fig

Pasha M, Eid AH, Eid AA, Gorin Y, Munusamy S, Orekhov AN

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