A randomized, double-blind, placebo-controlled trial in 153 older adults taking the antidepressant citalopram found daily supplementation with 500 g vitamin B 12 , 2 mg of folic acid, and 25 mg of vitamin B6 for one year did not reduce the severity of depressive symptoms but increased the response to drug treatment and helped to prevent symptom relapse (112), suggesting B-vitamin supplementation might provide some benefit as an adjunct therapy
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In the United Kingdom, vitamin B12 deficiency is relatively common, with prevalence varying depending on the population studied and the biochemical threshold used for diagnosis
Guidelines for safe and effective treatment
A: No, it should only be used under medical supervision as it is an injectable medication
11.Can You Use Vitamin b1, b6, and b12 Injection During Pregnancy