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While GLP-1 medicines, such as Semaglutide, specifically target the GLP-1 receptor, Tirzepatide targets both the GLP-1 and GIP receptors

Obesity Management Retatrutide is most notably being developed for weight loss

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GI symptoms typically improve with continued use

Dosage and medication selection must always be determined by a prescribing physician

Can J Physiol Pharmacol (2003) 81(11):100512.10.1139/y03-107 92 LittleTJDoranSMeyerJHSmoutAJODonovanDGWuKLet alThe release of GLP-1 and ghrelin, but not GIP and CCK, by glucose is dependent upon the length of small intestine exposed