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Patients experiencing rapid or significant weight loss on GLP-1 therapy may therefore face indirect effects on bone health

One year after discontinuation, patients treated for obesity had gained 0.5 % of their baseline weight, whereas those treated for T2DM had lost a further 1.3 %

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[PubMed: 34324435] Systematic Review in Orthopaedic Sports Medicine (2025): A systematic review of 36 studies from an orthopaedic sports medicine perspective found that BPC-157 consistently enhanced growth hormone receptor expression and angiogenesis-related pathways while reducing inflammatory cytokines

An interesting finding from a recent retrospective cohort study examined patients receiving botulinum toxin for overactive bladder

Our study demonstrates that direct cartilage protection is not only achievable but central to achieving therapeutic efficacy