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Energy balance hypotheses motivate indirect calorimetry (VO/VCO and RQ), activity monitoring, and brown-adipose thermogenic markers

Of note, the adaptor protein IRS1 not only binds to IGF-IR, but also interacts with EGFR/ErbB3

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That changed in 2017, when researchers confirmed the presence of Epitalon in native pineal gland extracts, a discovery that validated its endogenous origin and helped explain its overlap with, but also differences from, Epithalamin [7]