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Remember that clinical trials failed to demonstrate statistically significant weight loss in the largest study, leading to development termination in 2007

PMID 24771084

Clinical trials used structured titration schedules to minimize these side effects while allowing the body to adapt

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For example, supplements like omega-3 fatty acids and vitamin E have anticoagulant properties that might interact with medications such as oral contraceptives or metformin 61

Warren, and A.G