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NLRP3 inflammasome regulates release of IL-18 and IL-1 (pro-inflammatory cytokines) in macrophages and gets activated on receiving damage-associated molecular patterns (79)

Yet decades later, researchers still do not have a clear understanding of how DSIP may work, whether it has a meaningful physiological role in humans, or whether the early findings represent a reproducible biological effect

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Mechanistically, the peptide perturbs the FOXO4 interaction with p53, which selectively causes p53 nuclear exclusion and cell-intrinsic apoptosis (Figure 2, this novel senolytic did remove cells from the PDL9 chondrocytes, which was accompanied by significantly reduced levels of SA--gal staining

10.1016/j.vph.2018.02.010 76 VukojevicJ.VrdoljakB.MalekinusicD.SiroglavicM.MilavicM.KolencD.et al (2020)