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Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis
Patients often report: Persistent flushing Numbness or tingling in hands/feet Water retention Headaches Lethargy or disrupted sleep Because of its long half-life , these side effects dont wear off quickly , making it harder to adjust dosing
While their primary mechanism involves inhibiting glucose reabsorption in the kidney, their cardioprotective effects in MIRI are thought to be mediated by multiple pathways, including a significant contribution from reducing oxidative stress and inflammation (Pham et al., 2024
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