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Preprint at bioRxiv (2023)

The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases

Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors

HIF- survives degradation in the absence of oxygen and can dimerize with the always-available HIF-

This distinct mode of action is considered different from the broad activity observed in other compounds affecting opioid systems

Quick Answer: No formal contraindication exists for taking NAD+ supplements with tirzepatide, but this combination has not been studied in clinical trials and safety has not been established