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These observations were corroborated by single-cell calcium imaging studies in slices of arcuate nuclei, demonstrating that GLP-1MK-801 inhibits the NMDA-induced intracellular calcium surge relative to GLP-1 alone (Extended Data Fig

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Additionally, the metabolism of dopamine by monoamine oxidase (MAO) produces hydrogen peroxide (H 2 O 2 ), which can be converted to highly reactive hydroxyl radicals via Fenton reactions in the presence of transition metals [160]