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Additionally, very high doses of Vitamin C can theoretically increase the excretion of oxalate in the urine, which may be a concern for individuals with a history of oxalate kidney stones

Considering a new cell death process, called ferroptosis, xCT is an important inhibitor, since the accumulation of lipid peroxides activates ferroptosis and cysteine-derived glutathione is the substrate used by glutathione peroxidase 4 (GPX4) in the dissipation of lipids peroxides (117)

10.1371/journal.pone.0093814 PLoS One 169 ShaheenH.SobhyS.El MouslyS.AbuomiraM.MansourM

B., Baures, P

Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9

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