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Disruption of the microbial communities in the gut is frequently reported among IBD patients, and combined with the elevated levels of gut-derived LPS and bacterial DNA also detected, suggests that increased intestinal permeability also contributes to disease pathologies (Targan 2000

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Although these studies primarily focus on safety and tolerability, they also provide the first human data on pharmacokinetics and, early pharmacodynamic (biomarker)effects

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Obesity and type 2 diabetes: what can be unified and what needs to be individualized