As gut microbial imbalances and maladaptive host responses have been implicated in the pathology of obesity and diabetes, this study aimed to determine the effects of pharmacologically stimulated GLP-1 and GLP-2 receptor function on the gut microbiome composition in diet-induced obese (DIO) mice
Visiongain Insight: Competition in next-generation obesity therapies will increasingly depend on efficacy, preservation of lean mass, cardiovascular outcomes and dosing convenience
PMID: 35658024): The study showed mean weight reduction of 15.0% , 19.5% , 20.9% vs 3.1% placebo at 72 weeks The study showed up to 36% of participants achieved 25% or more weight loss with tirzepatide 15 mg Tirzepatide Once Weekly for the Treatment of Obesity in People with Type 2 Diabetes (SURMOUNT-2) , published in The Lancet (Garvey WT et al., 2023
The tasty way to get the benefits: Aim for at least two servings of beef, poultry, fish and eggs paired with two servings of cheese daily
Hydrogen water selectively neutralizes harmful reactive oxygen species while preserving beneficial signaling molecules
This suggests CJC-1295 may access satellite cell biology through an IGF-1-independent GH axis pathway of greater relevance in aged research contexts where GH secretion has declined