Safety and efficacy of memantine in children with autism: randomized, placebo-controlled study and open-label extension
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In turn, the abnormal aggregation of -synuclein has been shown previously to increase brain excitotoxicity by affecting the transport efficiency of glutamate transporters and increasing the phosphorylation of NMDARs 12 , thus generating a vicious cycle involving excessive brain glutamate, excitotoxicity, and aberrant -synuclein aggregation