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No treatment is required, but they may be indicative of a syndrome of greater significance Individuals with six or more large cafe-au-lait macules should be suspected of possibly having neurofibromatosis

Published pharmacokinetic data are most robust for this route, and the clinical track record is longest

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Two summaries of this questionnaire were used for this study: the summary of the mental aspects of SF-36 (SF-36 MCS) and the physical aspects of SF-36 (SF-36 PCS)