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For instance, chronic sodium butyrate supplementation in food (49, 51, 53, 54, 56) or orally delivered via gavage (50, 5759) reduces body weight gain and fat mass of mice fed with a HFD compared to mice fed with an HFD alone, suggesting that butyrate can prevent or contribute for the treatment of diet-induced obesity (DIO)

Mehmet Oz, Administrator of the Centers for Medicare & Medicaid Services, approved this document on November 20, 2025

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Similarly, SAD control group showed an abundance of Parasutterella a symbiont that supports intestinal mucosal stability with a potential protective role in anxiety (Butler et al., 2023