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The good news is that these are usually mild and short-lived, often improving as your body adjusts

Ozempic, though it has the same chemical composition as Wegovy, is approved for the treatment of diabetes

doi:10.1016/j.cmet.2013.04.008 2

Michael Baptista January 20, 2026 Meet Alex, a bariatric patient who lost an incredible 140 pounds and achieved a truly life-changing transformation

Throughout the study timeframe, 961 participants using GLP-1RAs developed depression, and 902 participants using SGLT2is developed depression

Weight loss effects of GLP-1RAs Liraglutide (3.0 mg, Saxenda), a GLP-1RA that activates the GLP-1 receptor, was approved by the FDA in December 2014 for adult obesity treatment [38] and has recently shown efficacy in adolescents aged 12 to 18 years