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Asymptomatic : In asymptomatic patients with risk factors (see Table 1: Patient Risk Factors Associated with B 12 Deficiency above) consider supplementation in lieu of testing

Some individuals may experience mild nausea or digestive discomfort

Comparative research indicates that GHK-Cu achieves collagen stimulation comparable to or exceeding that of tretinoin, with the advantage of having fewer irritancy concerns

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The Ottawa Hospital Sterne JA, Hernn MA, Reeves BC et al (2016) ROBINS-I: a tool for assessing risk of bias in non-randomized studies of interventions