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In general, in all treated conditions a drastic modulation of the MRAB biofilm architecture was evident, with enhanced disruption and an increase in dead (red) biofilm cells (Figure 3C and Supplementary Figure S3)

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You can't establish a therapeutic window if you're guessing how much of your compound actually survived the gut

[169] reported that SOCS1 and SOCS3 induced IR by inhibiting the phosphorylation of tyrosine moieties on IRS proteins in mouse adipocytes, muscle cells, and liver tissue

Shitara, D