I am Andrii Buvailo, and this is my weekly newsletter, Where Tech Meets Bio, where I talk about technologies, breakthroughs, and great companies moving the biopharma industry forward
GLP-1 receptor agonists (semaglutide, dulaglutide, liraglutide) work by mimicking a natural hormone that regulates blood glucose and appetite
Early research suggests that 5-Amino-1MQ works by reducing the activity of NNMT (nicotinamide N-methyltransferase), a naturally occurring enzyme found throughout the body that plays a crucial role in regulating cellular energy metabolism and fat storage within cells, as well as the rate at which your body burns through NAD+
Remarkably, all constructs retained the same localization patterns as seen in N2a cells: Go-Nt 7 and MGSLCSR-Nt 7 targeted mainly Golgi stacks labeled by GalT-mRFP, while MGNC-Nt 7 associated largely with the PM (Fig
Risk mitigation
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