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Studies indicate that GLP-1 receptor agonists may modulate the activity of multiple immune cells, including macrophages, neutrophils, and T lymphocytes
the research concluded that Results of this study suggest a modest increase in the risk of NAION among individuals with T2D associated with semaglutide use, smaller than that previously reported, and warranting further investigation into the clinical implications of this association. This research is in addition to another cohort research in 2025 finding an association between semaglutide usage and NAION in people diagnosed with diabetes
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