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For all NPs types, standardized methods for evaluating immune responses and long-term safety remain essential

In fact, it has been demonstrated that caspase-3 leads to ZO-1 and claudin-5 disruption in endothelial cells even in the absence of apoptotic death, indicating a non-apoptotic role in barrier regulation (Zehendner et al., 2011

Additionally, Rutin can reduce sorbitol, ROS, advanced glycation end-product precursors, and inflammatory cytokines, thereby preventing or treating diabetes and its complications (27)

Cancer Res 44 , 34033407 (1984)