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Gastrointestinal Effects Nausea (12 to 18%), diarrhea (12 to 17%), and vomiting (5 to 9%) in SURPASS trials arise predominantly from GLP-1R activation on vagal afferents and NTS neurons [14]

Proc Natl Acad Sci U S A 105:2085820863

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This enhanced bioavailability translates to more consistent neurotransmitter support, particularly during periods of acute stress when catecholamine depletion occurs rapidly

Early and structured dysphagia screening, alongside timely referral to professional dysphagia therapy, should be an integral part of care

Thymosin alpha-1 immune regulation would theoretically benefit the systemic autoimmune process driving both skin and joint involvement