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5.4 Mitochondrial dysfunction as an upstream driver of amyloid and tau pathology A significant shift in Alzheimer's disease (AD) research is represented by the Mitochondrial Cascade Hypothesis, which posits that mitochondrial dysfunction is the primary driver of AD pathophysiology, rather than a secondary consequence of Tau or A accumulation (94)
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For gastrointestinal goals , the oral route has a strong mechanistic rationale
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What Causes Free Radicals
MYQORZO (aficamten) , a cardiac myosin inhibitor for the treatment of adults with symptomatic obstructive hypertrophic cardiomyopathy (oHCM), inhibits force in cardiac muscle by altering myosin's biochemical activity without changing thick filament structure
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