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A 2024 network meta-analysis pooling 28 trials and 23,622 participants found that even tirzepatide 5 mg produced more weight loss than every studied semaglutide dose: 5.27 kg of loss at 5 mg tirzepatide versus a range of 2.52 to 4.97 kg across semaglutide doses from 0.5 to 2.0 mg

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