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SIRT1 is also known as the longevity gene because of its role in reducing the risk of diabetes, obesity, metabolic syndrome, atherosclerosis and other forms of cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer
Because NNMT occupies a central position within nicotinamide methylation pathways, it has become an important target for investigations involving enzyme regulation, methyl-donor utilization, cofactor-associated signaling networks, and methyltransferase pharmacology
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