Hello, this is Dr.Newcell
Upon bile acid activation, hepatic FXR induces expression of small heterodimer partner (SHP), which suppresses CYP7A1 and CYP8B1 gene transcription, thereby reducing bile acid synthesis (68)
The starting dose of 0.25 mg is intentionally low, meant to let your body adjust to the medication before the dose gradually increases over the following months
It facilitates the transportation of fatty acids into the mitochondria, where they are converted into usable energy
[See USP Controlled Room Temperature.] Distributed by Hospira, Inc., Lake Forest, IL 60045 USA LAB-0977-2.0 Revised: 08/2019
These drugs were designed for long-term use, so manufacturers havent provided formal instructions for stopping