Krishnan AV, Trump DL, Johnson CS, Feldman D
NAD + (nicotinamide adenine dinucleotide) What it is: NAD is a coenzyme naturally present in cells
It is valued for its potential to assist in reducing body fat while preserving lean muscle mass, making it a popular supplement among individuals pursuing weight management and fitness goals
In: Czuczwar SJ, editor
While gastrointestinal symptoms (nausea, vomiting, diarrhea, constipation) affect many patients initially, severe or persistent symptoms may necessitate dose adjustment, temporary dose reduction, or consideration of alternative therapies
Their beneficial mechanisms can include the attenuation of neuroinflammation [e.g., valproate via histone deacetylase (HDAC) inhibition in microglia, downregulating interleukin-1 beta (IL-1) and inducible nitric oxide synthase (iNOS)] or the mitigation of glutamatergic excitotoxicity coupled with enhancement of neurotrophic factor expression (e.g., lamotrigine), thereby conferring antidepressant-like potential (Mula and Sander, 2007
