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Therefore, a better understanding of the mitochondrial metabolic programmes critical in supporting cancer cell survival following 5FU treatment is required to rationally design more effective fluoropyrimidine-based chemotherapy combination regimens

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To identify 20S proteasome substrates in the human proteome, we applied this pipeline to lysates of HEK293T cells treated with FLAG-tagged 20S proteasomes, immunoprecipitated from the same type of cells

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