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For many people, the barrier to starting a GLP-1 therapy isn't about the medicine itself, it's about the needle

Discovery of a novel series of orally bioavailable and CNS penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) non-competitive antagonists based on a 1,3-disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione core

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CrossRef 15,940 View 556 Download 29 Web of Science Crossref Steatotic liver disease Abstract PDF Metabolic dysfunction-associated steatotic liver disease (MASLD) is a significant global health issue, affecting over 30% of the population worldwide due to the rising prevalence of metabolic risk factors such as obesity and type 2 diabetes mellitus

Neuroscience 170 , 12391248 (2010)