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Gallstone ileus Less than 0.5% of patients with gallstone, especially critical and elderly, are at risk of mechanical bowel obstruction due to the impaction of the stone passing through a biliaryenteric fistula due to recurrent episodes of cholecystitis

However, a longer duration of therapy should not preclude the possibility of an association to the drug since most studies included in the analysis did not continue beyond 24 weeks

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RF, riboflavin