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its blockade increases serotonin release Promotes neurogenesis : TREK-1 knockout mice show increased hippocampal neurogenesis, and PE-22-28 recapitulates this effect pharmacologically within 4 days of treatment Induces synaptogenesis : TREK-1 blockade promotes dendritic growth and synaptic connection formation PE-22-28 inhibits TREK-1 with an IC50 of 0.12 nM, making it approximately 300-500 times more potent than spadin

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Melatonin 2024:303322 Sabry NC et al (2024) Harnessing melatonergic agonists and antagonists: a dual approach to alleviating depression and depression-associated insomnia

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gift from Novo Nordisk) in a crossover study design (Figure 5A)