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GSH and apoptosis Apoptosis is the canonical form of regulated cell death, characterized by cell shrinkage, chromatin condensation, nuclear fragmentation, and the formation of membrane-enclosed apoptotic bodies 31

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For a standard 70 kg human, the calculated HED is 84.7 mg/day

Finally, combining low-dosage IKE with etanercept, a TNF inhibitor, triggered ferroptosis in FLS and delayed arthritis progression in the CIA model (133)