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Short-acting but not long-acting glucagon-like protein-1 receptor agonists are associated with increased development of GERD and Barretts esophagus: results from a global healthcare database

These results represent the greatest mean body-weight reduction reported to date for any incretin-based investigational therapy in a clinical trial of this duration.6 Although the triple-agonist mechanism offers substantial promise, glucagon receptor activation introduces theoretical safety concerns, including transient hyperglycemia, increased heart rate and potential hepatic effects

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Results are heterogeneous and depend on isomer composition, dose, and the population studied