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Patients with inborn errors of metabolism or reduced hepatic mitochondrial activity may be at an increased risk for hyperammonemia with or without encephalopathy

[67] Additionally, hCDR1 improved cognitive behavior and brain pathology in lupus mice [68] and downregulated the expression of the indoleamine 2, 3-dioxygenase (IDO) gene, which is increased in SLE patients

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Gallbladder Disease: Rapid weight loss combined with altered gut motility can increase the risk of gallstones or cholecystitis (gallbladder inflammation), which presents as sharp pain in the upper right portion of the abdomen