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The peptide's unusual gastric stabilitysurviving extreme pH conditionsdistinguishes it from most peptides, but in solution it remains susceptible to oxidation, hydrolysis, and bacterial contamination

Moreover, it was postulated that the aromatic ring of the 3-homotyrosine side chain and the C-terminal phenyl ring interact and Phe550 in IRAP further stabilizes aromatic/hydrophobic packing (Barlow et al., 2020)

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Cerebral Folate Deficiency (also known as CFD) is a fairly newly identified disorder in which there is low 5-MTHF (5-methyltetrahydrofolate) in the cerebrospinal fluid (CSF) but normal (or even elevated) 5-MTHF in the blood