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FOXO4-DRI is a cell-permeable peptide antagonist that blocks the interaction of FOXO4 and p53

This physical limitation makes it more difficult to effectively target cells and requires higher viral doses, which can raise safety issues and complicate manufacturing

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As of the FDAs 2023 Category 2 designations, injectable GHK-Cu was included among the peptides designated as having safety concerns for compounding

Rusiecki JA, Baccarelli A, Bollati V, Tarantini L, Moore LE, Bonefeld-Jorgensen EC