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Notoginsenoside Ft1 inhibits the PI3K/AKT/mTOR signaling pathway, activates the p38 MAPK and ERK1/2 signaling pathways, and increases the proportion of CD8 cells, thereby inducing + T apoptosis and lysosomal cell death in various cancer cells, and promoting angiogenesis

Elsevier, Philadelphia, pp 757-768.e6 Czarnecka-Chrebelska KH, Mukherjee D, Maryanchik S V, Rudzinska-Radecka M (2023) Biological and genetic mechanisms of COPD, its diagnosis, treatment, and relationship with lung cancer

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Quercetin promotes TFEB nuclear translocation and activates lysosomal degradation of ferritin to induce ferroptosis in breast cancer cells

It exists as reduced (GSH, active) and oxidised (GSSG, inactive) forms

cGPX4 and mGPX4 suppress ferroptosis in a context-dependent manner 94,98,99