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Front Aging Neurosci 108:198350 Athauda D, Maclagan K, Skene SS et al (2017) Exenatide once weekly versus placebo in Parkinsons disease: a randomised, double-blind, placebo-controlled trial
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Cagrilintide vs AOD 9604 Mechanism: Cagrilintide: Amylin receptor agonist (appetite/satiety) AOD 9604: HGH fragment (fat metabolism) Completely different Weight loss: Cagrilintide: 10-12% body weight AOD 9604: 5-8% body weight (less robust data) Cagrilintide superior Clinical evidence: Cagrilintide: Extensive Phase 2/3 trials AOD 9604: Limited clinical data Cagrilintide better studied Side effects: Cagrilintide: GI effects common AOD 9604: Minimal side effects AOD 9604 better tolerated Combination potential: Could theoretically combine (different mechanisms) No clinical data on combination Cagrilintide + semaglutide better established Verdict: Cagrilintide more powerful, better evidence
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The problem is that levels decline sharply with age by around 60% between our 20s and 60s
On the other hand, a weak immune system results in a slow wound-healing process
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