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Across the cagrilintide clinical program, the dominant tolerability issues have been gastrointestinal: nausea, reduced appetite, constipation, and, less commonly, vomiting a profile shared with pramlintide and with GLP-1 agonists, and mechanistically expected from a compound that slows the stomach and engages the area postrema

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We provide ongoing support and regular assessments to adapt your plan as needed and ensure continued progress towards your weight goals

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In phase 2 trials, orforglipron achieved up to 14.7% mean weight reduction at 36 weeks in adults with obesity or overweight, in line with the mid-teens weight reduction from NVOs higher dose oral semaglutide , as well as the injectables currently in the market

Proper storage helps maintain its effectiveness and extends its shelf life up to 36 months